Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 3
Phospho-DAB1 (Tyr220) Antibody (PA5-104586) in IHC (P)
Immunohistochemistry analysis of Phospho-DAB1 (Tyr220) in mouse colorectal tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-DAB1 (Tyr220) polyclonal antibody (Product # PA5-104586) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-104586
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DAB1(Accession O75553), corresponding to amino acid residues around phosphorylated Tyr220.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2816061
Product Specific Information
Antibody detects endogenous levels of Dab1 only when phosphorylated at Tyr220.
Target Information
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Dab reelin signal transducer 1; Dab, reelin signal transducer, homolog 1; Disabled homolog 1; mDab1; RP23-356E21.1; yotari
Gene Aliases: AI956902; C630028C02Rik; DAB1; scm; scr; scrambler; yot
UniProt ID: (Human) O75553, (Rat) Q8CJH2, (Mouse) A2A970
Entrez Gene ID: (Human) 1600, (Rat) 266729, (Mouse) 13131
negative regulation of cell adhesion
small GTPase mediated signal transduction
midgut development
adult walking behavior
dendrite development
ventral spinal cord development
cerebellum structural organization
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
radial glia guided migration of Purkinje cell
response to drug
positive regulation of neuron differentiation
positive regulation of protein kinase activity
negative regulation of JAK-STAT cascade
negative regulation of astrocyte differentiation
negative regulation of axonogenesis
Golgi localization
lateral motor column neuron migration
neuron migration
brain development
cerebral cortex cell migration
cerebral cortex radially oriented cell migration
cerebral cortex development
multicellular organism development
nervous system development
central nervous system development
cell differentiation
intracellular signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support