|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of Serine637(K-L-S(p)-A-R) derived from Human DRP1.|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
A suggested positive control for Western blot is JK or K562 cells.
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Collapsin response mediator protein 1; CRMP-1; dihydropyrimidinase related protein-1; dihydropyrimidinase-like 1; Dihydropyrimidinase-related protein 1; DPYSL1; DRP-1; DRP1; ULIP-3; Unc-33-like phosphoprotein 3
Gene Aliases: CRMP-1; CRMP1; DPYSL1; DRP-1; DRP1; ULIP-3; ULIP3
UniProt ID: (Human) Q14194
Entrez Gene ID: (Human) 1400
Molecular Function: hydrolase
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.