|Western Blot (WB)||1:500-1:2000|
|Tested Species reactivity||Rat, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from human EFNB1/2 around the phosphorylation site of Tyrosine 330|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EFL-3; EFNB2; ELF2; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; EPH-related receptor tyrosine kinase ligand 5; ephrin-B1; ephrin-B2; Ephrin-B2 precursor; EPL5; EPLG5; HTK ligand; HTK-L; HTKL; kinase ephrin-B2; LERK-2; LERK-5; LERK5; ligand of eph-related kinase 2; ligand of eph-related kinase 5
Gene Aliases: Cek5-L; CFND; CFNS; EFL-3; EFL3; ELF-2; Elk-L; Epl2; Epl5; EPLG2; EPLG5; Htk-L; HTKL; LERK-2; LERK-5; LERK2; LERK5; NLERK-1; RP11-272L14.1; RP3-496G1.1; Stra1
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