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7TM Antibodies
Phospho-Endothelin Receptor B (Ser435, Ser436) Polyclonal Antibody
FIGURE: 1 / 1
Phospho-Endothelin Receptor B (Ser435, Ser436) Antibody (7TM0220A) in WB
Agonist-induced Serine435/Serine436 phosphorylation of the Endothelin Receptor B. Upper panel, HEK293 cells stably expressing the Endothelin receptor B (ETB) were either not exposed or exposed to 100 nM Endothelin 1 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS435/pS436-ETB antibody (7TM0220A) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed with an phosphorylation... View More
Product Details
7TM0220A
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human ETB around the phosphorylation site of Ser435/Ser436.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AU022549; Endothelin receptor non-selective type; endothelin receptor subtype B1; Endothelin receptor type B; ET-B; Et-b receptor; Et-b-r; ET-RB; Etb receptor; Etb-svr; RP11-318G21.1
Gene Aliases: ABCDS; EDNRB; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB; HSCR; HSCR2; WS4A
UniProt ID: (Human) P24530
Entrez Gene ID: (Human) 1910
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
positive regulation of protein phosphorylation
regulation of pH
cell surface receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
nervous system development
peripheral nervous system development
posterior midgut development
aging
regulation of blood pressure
positive regulation of cell proliferation
negative regulation of neuron maturation
response to organic cyclic compound
vein smooth muscle contraction
sensory perception of pain
cGMP-mediated signaling
melanocyte differentiation
regulation of fever generation
negative regulation of cellular protein metabolic process
enteric smooth muscle cell differentiation
positive regulation of urine volume
positive regulation of renal sodium excretion
epithelial fluid transport
vasoconstriction
vasodilation
negative regulation of apoptotic process
macrophage chemotaxis
response to pain
enteric nervous system development
regulation of epithelial cell proliferation
regulation of sensory perception of pain
positive regulation of penile erection
cellular response to lipopolysaccharide
endothelin receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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