EPHA3 (EPA receptor A3), also known as ETK, HEK, ETK1, HEK4, TYRO4, is belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 binds ephrin-A ligands.
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Protein Aliases: EK4; EPH-like kinase 4; Eph-like tyrosine kinase 1; Ephrin type-A receptor 3; H TYRO4; HEK; Human embryo kinase; human embryo kinase 1; testicular tissue protein Li 64; TYRO4 protein tyrosine kinase; Tyrosine-protein kinase receptor ETK1; Tyrosine-protein kinase TYRO4
Gene Aliases: EK4; EPHA3; ETK; ETK1; HEK; HEK4; TYRO4
UniProt ID: (Human) P29320
Entrez Gene ID: (Human) 2042