Eph receptors and ephrins exhibit complementary expression in many tissues during embryogenesis indicating that bidirectional activation of Eph receptors and ephrin-B proteins may occur at expression domain interfaces. Ephrin-B1 transduces outside-in signals through C-terminal protein interactions that effect integrin-mediated cell attachment and migration. The distribution of ephrin-B1 in the developing retina suggests that it influences retinal axon mapping along the dorsal-ventral axis and may be involved in intratectal development The transmembrane ligand ephrin-B2 and its receptor tyrosine kinase EphB4 are specifically expressed on arterial and venous endothelial cells, respectively.
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Protein Aliases: CAPB; CEK5 receptor ligand; CEK5-L; EFL-3; ELF-2; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; EPH-related receptor tyrosine kinase ligand 5; EPHB2, Ephrin type-B receptor 1; EPHB3, DRT; Ephrin-B1; Ephrin-B1 C-terminal fragment; Ephrin-B1 CTF; Ephrin-B1 ICD; Ephrin-B1 intracellular domain; Ephrin-B2; EPHT3; ERK; ETK2; HEK2; Hek5; HTK ligand; HTK-L; LERK-2; LERK-5; ligand of eph-related kinase 5; MGC87492; NET, HEK-6, ELK, Ephrin type-B receptor 2, Ephrin B1, EphrinB1, Ephrin B2, EphrinB2; PCBC; Stimulated by retinoic acid gene 1 protein; Tyro5; TYRO6
Gene Aliases: Cek5-L; CFND; CFNS; EFB1; EFL-3; EFL3; EFNB1; EFNB2; ELF-2; Elf2; Elk-L; Epl2; Epl5; EPLG2; EPLG5; Htk-L; HTKL; LERK-2; LERK-5; LERK2; LERK5; NLERK-1; Stra1