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Invitrogen
Phospho-Ezrin/Radixin/Moesin (Thr558) Polyclonal Antibody
Product Details
PA5-38679
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human Moesin/Ezrin/Radixin around the phosphorylation site of Thr558 (Y-K-TP-L-R)
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2555274
Target Information
Moesin, a member of the talin-4.1 superfamily, is a linking protein of the submembraneous actin cytoskeleton. It is expressed in macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines but not in blood cells. It is involved in cell adhesion, migration, and organization of cell surface structures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytovillin; cytovillin 2; epididymis luminal protein 70; epididymis secretory protein Li 105; ESP10; Ezrin; Membrane-organizing extension spike protein; Moesin; p81; Radixin; radixin isoform; villin 2; villin 2 (ezrin); Villin-2
Gene Aliases: AA516625; AW146364; C78546; CVIL; CVL; DFNB24; EZR; HEL-S-105; HEL70; MSN; p81; R75297; RDX; VIL2
UniProt ID: (Human) P15311, (Mouse) P26040, (Rat) P31977, (Human) P26038, (Rat) O35763, (Mouse) P26041, (Human) F5H1A7, (Mouse) P26043
Entrez Gene ID: (Human) 7430, (Mouse) 22350, (Rat) 54319, (Human) 4478, (Rat) 81521, (Mouse) 17698, (Human) 5962, (Rat) 315655, (Mouse) 19684
Molecular Function:
actin or actin-binding cytoskeletal protein
negative regulation of transcription from RNA polymerase II promoter
intestinal D-glucose absorption
sphingosine-1-phosphate signaling pathway
cytoskeletal anchoring at plasma membrane
leukocyte cell-cell adhesion
axon guidance
regulation of cell shape
regulation of cell size
positive regulation of gene expression
protein kinase A signaling
gland morphogenesis
membrane to membrane docking
microvillus assembly
astral microtubule organization
actin cytoskeleton reorganization
receptor internalization
regulation of microvillus length
regulation of actin cytoskeleton organization
cellular protein complex localization
positive regulation of multicellular organism growth
cortical microtubule organization
establishment of epithelial cell apical/basal polarity
filopodium assembly
phosphatidylinositol-mediated signaling
positive regulation of protein secretion
negative regulation of T cell receptor signaling pathway
actin filament bundle assembly
establishment of centrosome localization
establishment of endothelial barrier
negative regulation of ERK1 and ERK2 cascade
cellular response to cAMP
protein localization to cell cortex
establishment of protein localization to plasma membrane
positive regulation of establishment of protein localization to plasma membrane
negative regulation of interleukin-2 secretion
regulation of NIK/NF-kappaB signaling
regulation of organelle assembly
terminal web assembly
positive regulation of protein localization to early endosome
positive regulation of cellular protein catabolic process
negative regulation of p38MAPK cascade
positive regulation of early endosome to late endosome transport
establishment or maintenance of apical/basal cell polarity
epithelial cell differentiation
movement of cell or subcellular component
cytoskeleton organization
leukocyte migration
cellular response to testosterone stimulus
positive regulation of podosome assembly
regulation of lymphocyte migration
positive regulation of cell migration
regulation of actin filament bundle assembly
regulation of Rap protein signal transduction
negative regulation of homotypic cell-cell adhesion
negative regulation of GTPase activity
regulation of GTPase activity
apical protein localization
establishment of protein localization
negative regulation of cell size
actin filament capping
cellular response to thyroid hormone stimulus
cell-cell adhesion
regulation of ruffle assembly
positive regulation of G1/S transition of mitotic cell cycle
negative regulation of adherens junction organization
cellular response to platelet-derived growth factor stimulus
barbed-end actin filament capping
actin binding
protein binding
microtubule binding
protein domain specific binding
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
S100 protein binding
poly(A) RNA binding
cell adhesion molecule binding
actin filament binding
ATPase binding
cadherin binding involved in cell-cell adhesion
cytoskeletal protein binding
protein complex binding
structural molecule activity
double-stranded RNA binding
receptor binding
structural constituent of cytoskeleton
protein kinase binding
protein binding, bridging
protein homodimerization activity
protein kinase A binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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