|Tested species reactivity||Hamster, Human, Mouse, Pig, Rat|
|Published species reactivity||Chicken|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide corresponding to residues surrounding pTyr397 of human FAK|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
It is not recommended to aliquot this antibody.
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Focal adhesion kinase as a mechanotransducer during rapid brain growth of the chick embryo.
PA5-17084 was used in immunohistochemistry and western blot to study the pressure-induced changes in focal adhesion kinases expression in embryonic neuroepithelium
|Desmond ME,Knepper JE,DiBenedetto AJ,Malaugh E,Callejo S,Carretero R,Alonso MI,Gato A||The International journal of developmental biology (58:35)||2014|