This antibody is predicted to react with mouse, bovine and zebrafish based on sequence homology.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
FoxA2 is a transcription factor, which belongs to forkhead family of DNA binding proteins and also a member FoxA subfamily. Apart from the centrally located forkhead box domain, FoxA2 protein has conserved activation domain II and III at the C-terminus and conserved activation domain IV and V are located at the N-terminus. FoxA2 proteins interact with histones H3 and H4 through C-terminal region and displace nucleosomal histones to remodel chromatin and recruit cell-type restricted factors to initiate gene expression that confers cell and tissue type identities. FoxA2 play a key role in regulation of glucose and lipid metabolism and energy balance at the organism level. FoxA2 exert its glucose and lipid homeostasis function by regulating genes at the metabolically active sites such as, liver, pancreatic alpha and beta cells and adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; TCF-3B; TCF3B; Transcription factor 3B
Gene Aliases: FOXA2; HNF3B; TCF3B
UniProt ID: (Human) Q9Y261
Entrez Gene ID: (Human) 3170