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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide derived from human Filamin 1 around the phosphorylation site of Serine 2152|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous protein at a molecular weight of 280 kDa.
Purity is >95% by SDS-PAGE.
Caldesmon, Filamin 1, nebulin and villin are differentially expressed and regulated Actin binding proteins. Both muscular (CDh) and non-muscular (CDl) forms of caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and Myosin. CDh is expressed predominantly on thin filaments in smooth muscle, whereas CDl is widely expressed in nonmuscle tissues and cells. Filamin 1, which is ubiquitously expressed and exists as a homodimer, functions to crosslink Actin to filaments. Nebulin is a large filamentous protein specific to muscle tissue that may function as a ruler for filament length. Several isoforms of nebulin, ranging from 700 to 900 kDa, are produced by alternative exon usage. Villin is Ca2+-regulated and is the major structural component of the brush border of absorptive cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ABP-280; actin binding protein 280; Actin-binding protein 280; alpha filamin; Alpha-filamin; dilated pupils 2; Endothelial actin-binding protein; Filamin A; filamin A, alpha; Filamin-1; Filamin-A; FilaminA; FLN; FLN-A; FLN1; FLNA; Non-muscle filamin
ABP-280; ABPX; CSBS; CVD1; Dilp2; F730004A14Rik; filamin-1; FLN; FLN-A; FLN1; FLNA; FMD; GENA 379; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD