MA5-14812 detects Phospho-GAB1 pTyr627 in human samples. Predicted to react with mouse and rat based on sequence homology.
MA5-14812 has been successfully used in Western blot applications.
The MA5-14812 immunogen is synthetic phosphopeptide corresponding to residues surrounding Tyr627 of human Gab1.
MA5-14812 detects Phospho-Gab1 (Tyr627) which has a predicted molecular weight of approximately 110 kDa.
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GRB2-associated binder 1; GRB2-associated binding protein 1; GRB2-associated binding protein 1 long isoform; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1; OTTHUMP00000220263
Gene Aliases: AA408973; AW107238; GAB1
Molecular Function: transmembrane receptor regulatory/adaptor protein