|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic phosphopeptide derived from human GRB10 around the phosphorylation site of Tyr67 (S-L-YP-S-A)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GRB10; GRB10 adapter protein; GRB10 adaptor protein; GRBIR; Growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; KIAA0207; maternally expressed gene 1; Maternally expressed gene 1 protein
Gene Aliases: 5730571D09Rik; AI325020; Grb-10; GRB-IR; GRB10; GRBIR; IRBP; KIAA0207; MEG1; mKIAA0207; RSS
Molecular Function: transmembrane receptor regulatory/adaptor protein
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