Phospho-GRK2 (Tyr86) Polyclonal Antibody detects endogenous levels of GRK2 only when phosphorylated at Tyr86.
Beta-adrenergic receptor kinase 1 (BARK1) phosphorylates the G-protein coupled b-adrenergic receptor. The b-adrenergic receptor is the primary target of epinephrine in cardiac muscle and other tissues. Elevated levels of BARK1 have been found in failing human heart tissue along with decreased activity of BAR. Knockout studies show that inhibition of BARK1 in Csq mice with severe cardiomyopathy markedly extended lifespan and improve cardiac health. This protein has also been referred to as G Protein Coupled Receptor Kinase 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK; BARK1; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; Beta-ARK-1; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2; GRK2
Gene Aliases: Adrbk-1; ADRBK1; BARK; Bark-1; BARK1; beta ARK; BETA-ARK1; betaARK1; GRK-2; GRK2