|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of Serine 417(L-E-M(p)-A-Q) derived from Human Girdin .|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for IHC is human breast carcinoma.
Girdin (girders of actin filements), also known as APE and GIV, is a widely expressed cytosolic protein and plays a key modulating role for the AKT-mTOR signaling pathway. Girdin is membrane-associated and interacts with phosphoinositides. Four isoforms of Girdin have been reported. GIV (pY175) is overexpressed in some human cancers such as colon, breast, and pancreatic carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.