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Western blot analysis of Phospho-GluR4 pSer862 using Phospho-GluR4 pSer862 polyclonal antibody (Product # PA5-36807) at a dilution of 1:500. Lane 1: MCF-7 cell lysate treated with Forskolin (10nM, 24h), Lane 2: Mouse spleen tissue lysate, Lane 3: Rat spleen tissue lysate.
|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide derived from human GluR4 around the phosphorylation site of Serine 862|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous protein at a molecular weight of 100 kDa.
Purity is >95% by SDS-PAGE.
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
AMPA 4; AMPA-selective glutamate receptor 4; GluA4; gluR-4; gluR-D; GLUR4; glutamate receptor 4; glutamate receptor channel alpha 4; Glutamate receptor ionotropic; glutamate receptor ionotropic, AMPA 4; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA4 (alpha 4); GRIA4; spike wave 1
GluA4; Glur-4; GluR-D; GLUR4; GLUR4C; Gluralpha4; GLURD; GRIA4; spkw1