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Western blot analysis of Phospho-Glucocorticoid Receptor pSer203 in Dexamethasone-treated A549 whole cell lysates with a blocking peptide (lane 1) and no blocking peptide (lane 2) using a Phospho-Glucocorticoid Receptor pSer203 polyclonal antibody (Product # PA5-35809).
|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from human GR around the phosphorylation site of Serine 203|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
GCCR; GCR; glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; glucocorticoid receptor 1; GR; GRL; NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
GCCR; GCR; GR; GRL; Grl-1; Grl1
Nucleoside, nucleotide and nucleic acid metabolism mRNA transcription mRNA transcription regulation Signal transduction Cell communication Steroid hormone-mediated signaling Immunity and defense Stress response Homeostasis Glucose homeostasis