This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
A suggested positive control for Western blot is 293 cells; suggested positive control for IHC is human breast carcinoma.
The homology between synthetic peptide sequence and rat is 100% .
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Antigen NY-CO-9; DKFZp779K1053; HD5; HDAC; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; histone deacetylase 4; histone deacetylase 4/5-related protein; Histone deacetylase 5; histone deacetylase 7; histone deacetylase mHDA1; KIAA0744
Gene Aliases: AI426555; HD5; Hdac4; HDAC5; KIAA0600; mHDA1; mKIAA0600; NY-CO-9
UniProt ID: (Human) Q9UQL6