Invitrogen

Phospho-HIPK1/HIPK2/HIPK3 (Tyr352, Tyr361, Tyr359) Polyclonal Antibody

View all (3) HIPK1/HIPK2/HIPK3 antibodies
Datasheet
Protocols
Questions & Answers
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-105887

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HIPK1(Accession Q86Z02), corresponding to amino acid residues around phosphorylated Tyr352.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2817286

Product Specific Information

Antibody detects endogenous levels of HIPK1/2/3 only when phosphorylated at Tyr352/361/359.

Target Information

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Androgen receptor-interacting nuclear protein kinase; ANPK; Fas-interacting serine/threonine-protein kinase; FIST; HCMV-interacting protein; hHIPk2; hipk1 {ECO:0000312|EMBL:ABO47653.1}; homeodomain interacting protein kinase 1-like protein; Homeodomain-interacting protein kinase 1; Homeodomain-interacting protein kinase 2; Homeodomain-interacting protein kinase 3; Homolog of protein kinase YAK1; Nbak3; nuclear body associated kinase 2b; Nuclear body-associated kinase 1; Nuclear body-associated kinase 2; Nuclear body-associated kinase 3; nuclear serine/threonine protein kinase; Protein kinase Myak; Sialophorin tail-associated nuclear serine/threonine-protein kinase

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Gene Aliases: 1110014O20Rik; 1110062K04Rik; ANPK; B230339E18Rik; DYRK6; Fist; FIST3; HIPK1; HIPK2; HIPK3; KIAA0630; mir-1902; MYAK; Nbak1; NBAK2; PKY; PRO0593; Stank; YAK1

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UniProt ID: (Human) Q86Z02, (Human) Q9H2X6, (Human) Q9H422, (Mouse) O88904, (Mouse) Q9QZR5, (Mouse) Q9ERH7, (Rat) O88850

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Entrez Gene ID: (Human) 204851, (Human) 28996, (Human) 10114, (Rat) 365895, (Mouse) 15257, (Rat) 362342, (Mouse) 15258, (Mouse) 15259, (Rat) 83617

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Function(s)
protein serine/threonine kinase activity protein binding ATP binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity transcription corepressor activity protein kinase activity SMAD binding virion binding nucleotide binding DNA binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation apoptotic process mRNA transcription phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation negative regulation of apoptotic process positive regulation of DNA binding negative regulation of JUN kinase activity smoothened signaling pathway positive regulation of cell proliferation anterior/posterior pattern specification regulation of tumor necrosis factor-mediated signaling pathway retina layer formation neuron differentiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator embryonic camera-type eye morphogenesis embryonic retina morphogenesis in camera-type eye lens induction in camera-type eye iris morphogenesis endothelial cell apoptotic process extrinsic apoptotic signaling pathway positive regulation of protein phosphorylation DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator transforming growth factor beta receptor signaling pathway adult walking behavior adult locomotory behavior positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway positive regulation of protein binding negative regulation of neuron apoptotic process positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade voluntary musculoskeletal movement positive regulation of sequence-specific DNA binding transcription factor activity SMAD protein signal transduction eye development modulation by virus of host morphology or physiology erythrocyte differentiation PML body organization regulation of cell cycle cellular response to hypoxia intrinsic apoptotic signaling pathway regulation of signal transduction by p53 class mediator adherens junction assembly definitive hemopoiesis cellular response to DNA damage stimulus negative regulation of nucleic acid-templated transcription
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