This Antibody was verified by KnockOut to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with Dog, Rabbit, Pig, Mouse, Rat, Bovine and Goat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Ikk alpha/beta is encoded by CHUk (conserved helix-loop-helix ubiquitous kinase) and Ikk B (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans. Upon stimulation by agents that activate the NF- kB pathway such as TNF alpha, the two subunits of Ikk complex, Ikk alpha and Ikk beta alongside a regulator NEMO (Ikk gamma) phosphorylates I-kappa-B proteins. This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus. Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation change that is required for the activation of the kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: I-kappa-B kinase 1; I-kappa-B kinase 2; I-kappa-B kinase-alpha; I-kappa-B-kinase beta; IkB kinase alpha subunit; IKK-a kinase; IKK-B; IKKA; nuclear factor NF-kappa-B inhibitor kinase beta; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; TCF17; transcription factor 16
Gene Aliases: IKBKA; IKK-alpha; IKK-beta; IKK1; IKK2; IKKA; IKKB; IMD15; NFKBIKA; NFKBIKB; TCF16