A suggested positive control for IHC is human brain tissue.
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
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Protein Aliases: FIP-3; FIP3; I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; IkB kinase gamma subunit; ikB kinase subunit gamma; IkB kinase-associated protein 1; IKBKG; IKK-gamma; IKKAP1; IKKG; incontinentia pigmenti; Inhibitor of nuclear factor kappa-B kinase gamma subunit; Inhibitor of nuclear factor kappa-B kinase subunit gamma; mF; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; NF-kappaB essential modifier; NF-kappaB essential modulator
Gene Aliases: AMCBX1; FIP-3; FIP3; Fip3p; IKBKG; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
UniProt ID: (Human) Q7LBY6
Entrez Gene ID: (Human) 8517