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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide derived from human IL-3R beta around the phosphorylation site of Tyrosine 593|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous protein at a molecular weight of 97 and 130 kDa.
Purity is >95% by SDS-PAGE.
Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific alpha subunit (IL-3R alpha) and a signal transducing beta subunit (IL-3R beta) common to the IL-3/IL-5/GM-CSF receptors. The alpha subunits are low-affinity ligand-binding proteins while the beta subunits do not themselves bind ligand, but are required for high affinity binding by the alpha subunits. The mouse IL-3 receptor has two distinct beta subunits, one that functions only in IL-3-mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine beta subunits are 91% homologous at the amino acid level but only 56% homologous to the human beta subunit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
beta common cytokine receptor; CD131; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); colony-stimulating factor-2 receptor, beta, low-affinity; CSF2RB; GM-CSF/IL-3/IL-5 receptor common beta subunit; GM-CSF/IL-3/IL-5 receptor common beta-chain; IL3R beta; IL3RB; IL5RB; interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
CD131; CDw131; CSF2RB; IL3RB; IL5RB; SMDP5