This antibody is predicted to react with human and mouse based on sequence homology.
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 4,5-trisphosphate receptor type 1; Inositol 1; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; INSP3R1; IP-3-R; IP3 receptor; IP3 receptor isoform 1; IP3R 1; ITPR1; protein phosphatase 1, regulatory subunit 94; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Gene Aliases: ACV; CLA4; I145TR; InsP3R; INSP3R1; IP3R; IP3R1; ITPR1; P400; PPP1R94; SCA15; SCA16; SCA29