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IR/IGF1R [pY1158] and IR/IGF1R [pYpY1162/63] phosphospecific antibodies. CHO-T cell extracts transfected with an IR vector either unstimulated (-) or stimulated (+) with insulin (Cat. no. 55-150) were immunoblotted with phosphospecific antibodies to IR/IGF1R. IR/IGF1R [pY1158] (1, 3). IR/IGF1R [pYpY1162/1163] (2, 4).
|Tested species reactivity||Human|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide derived from the region of IR/IGF1R that contains tyrosine 1158 of the human insulin receptor (IR)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol|
|Contains||0.05% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of alpha- and beta-subunits, which are disulfide-linked in a beta-alpha-alpha-beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Leukocyte antigen-related deficiency enhances insulin-like growth factor-1 signaling in vascular smooth muscle cells and promotes neointima formation in response to vascular injury.
||Niu XL,Li J,Hakim ZS,Rojas M,Runge MS,Madamanchi NR||The Journal of biological chemistry (282:19808)||2007|
IR, insulin receptor, IGF-I receptor, insulin-like growth factor 1 receptor, insulin-like growth factor I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2, IGF1 Receptor, IGF-I Receptor, IGF1R, CD221, IGFIR, IGFR, JTK13, CD220, HHF5, INSR, Insulin receptor
CD220, IGFIR, IGFR, JTK13, HHF5, CD221
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Cell surface receptor mediated signal transduction Receptor protein tyrosine kinase signaling pathway Developmental processes Embryogenesis Cell cycle Cell cycle control Apoptosis Inhibition of apoptosis Cell proliferation and differentiation