|Tested species reactivity||Human, Mouse|
|Published species reactivity||Rat, Mouse, Human, Chicken|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide derived from the region of IR/IGF1R that contains tyrosines 1158, 1162 and 1163 of the human insulin receptor (IR)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 50% glycerol, 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of alpha- and beta-subunits, which are disulfide-linked in a beta-alpha-alpha-beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Heat stress acutely activates insulin-independent glucose transport and 5'-AMP-activated protein kinase prior to an increase in HSP72 protein in rat skeletal muscle.
44-806G was used in western blot to investigate the effect of heat shock on glucose metabolism by skeletal muscles
|Goto A,Egawa T,Sakon I,Oshima R,Ito K,Serizawa Y,Sekine K,Tsuda S,Goto K,Hayashi T||Physiological reports (3:null)||2015|
¿6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.
44-806G was used in western blot to
|Basu S,Rajakaruna S,De Arcangelis A,Zhang L,Georges-Labouesse E,Menko AS||The Journal of biological chemistry (289:3842)||2014|
|Mouse||Not Cited||In vivo role of focal adhesion kinase in regulating pancreatic ß-cell mass and function through insulin signaling, actin dynamics, and granule trafficking.||Cai EP,Casimir M,Schroer SA,Luk CT,Shi SY,Choi D,Dai XQ,Hajmrle C,Spigelman AF,Zhu D,Gaisano HY,MacDonald PE,Woo M||Diabetes (61:1708)||2012|
Insulin-like growth factor receptor-1 and nuclear factor ¿B are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation.
44-806G was used in western blot to show that IGF-R/NFκB signaling regulates the level of caspase-3 activation during cell differentiation.
|Basu S,Rajakaruna S,Menko AS||The Journal of biological chemistry (287:8384)||2012|
|In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors.||Wu JD,Odman A,Higgins LM,Haugk K,Vessella R,Ludwig DL,Plymate SR||Clinical cancer research : an official journal of the American Association for Cancer Research (11:3065)||2005|