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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic phosphopeptide derived from human JIP1around the phosphorylation site of Thr103 (G-D-TP-P-G)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
C-Jun-amino-terminal kinase-interacting protein 1; IB-1; IB1; islet-brain 1; islet-brain-1; JIP-1-related protein; JIP1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; JRP; mitogen activated protein kinase 8 interacting protein; mitogen activated protein kinase 8 interacting protein 1; mitogen-activated protein kinase 8-interacting protein 1; PRKM8 interacting protein; PRKM8IP; protein kinase, mitogen-activated 8 interacting protein
IB1; JIP-1; JIP1; Mapk8ip; MAPK8IP1; mjip-2a; PRKM8IP; Skip