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Phospho-KIF1B (Ser1057) Antibody (PA5-105403) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-KIF1B (Ser1057) in human kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-KIF1B (Ser1057) polyclonal antibody (Product # PA5-105403) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-105403
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KIF1B(Accession O60333), corresponding to amino acid residues around phosphorylated Ser1057.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2816831
Product Specific Information
Antibody detects endogenous levels of KIF1B only when phosphorylated at Ser1057.
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF1B is a member of the KIF1/Unc104 family of kinesin-like proteins that are involved in the transport of mitochondria or synaptic vesicles in axons. KIF1B is an amino-terminal-type motor protein that is ubiquitously expressed, with the most abundant levels in differentiated nerve cells. The human KIF1B gene maps to chromosome 1p36. 2. Defects in axonal transport due to mutations at the KIF1B gene can underlie the human peripheral neuropathy phenotype. The mouse KIF1B gene generates an alternatively spliced transcript, which produces two isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: kinesin heavy chain member 1B; kinesin superfamily protein KIF1B; kinesin-family protein KIF1Bbeta3; Kinesin-like protein KIF1B; Klp; N-3 kinesin
Gene Aliases: A530096N05Rik; AI448212; AI506502; CMT2; CMT2A; CMT2A1; D4Mil1e; HMSNII; KIAA0591; KIAA1448; KIF1B; KIF1Bp130; KIF1Bp204; KLP; NBLST1
UniProt ID: (Human) O60333, (Rat) O88658, (Mouse) Q60575
Entrez Gene ID: (Human) 23095, (Rat) 117548, (Mouse) 16561
microtubule motor activity
protein binding
ATP binding
microtubule binding
ATPase activity
kinesin binding
phosphogluconate dehydrogenase (decarboxylating) activity
ATP-dependent microtubule motor activity, plus-end-directed
protein heterodimerization activity
NADP binding
nucleotide binding
microtubule binding motor protein
apoptotic process
microtubule-based movement
neuron-neuron synaptic transmission
neuromuscular synaptic transmission
anterograde axonal transport
cytoskeleton-dependent intracellular transport
mitochondrion transport along microtubule
pentose-phosphate shunt
metabolic process
vesicle-mediated transport
oxidation-reduction process
embryo development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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