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Invitrogen
Phospho-KSR1 (Ser392) Recombinant Rabbit Monoclonal Antibody (KSR1S392-3A4)
FIGURE: 1 / 3
Phospho-KSR1 (Ser392) Antibody (MA5-37016) in Flow
Flow cytometry of Phospho-KSR1 (Ser392) using HeLa human adenocarcinoma cells. Samples were incubated in monoclonal Phospho-KSR1 (Ser392) antibody (Product # MA5-37016) with a dilution of 0.1 µg/mL. Images correspond with the following conditions: untreated, unstained negative control (blue), treated with lambda phosphatase and stained (red), untreated and stained (green).
Product Details
MA5-37016
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
KSR1S392-3A4
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser392 of human phospho KSR1.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2896951
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAP kinase; HB protein; kinase KSR1; Kinase suppressor of Ras 1; mKSR1; OTTHUMP00000162931; Protein Hb
Gene Aliases: AW492498; B-KSR1; D11Bhm183e; D11Bhm184e; hb; KSR; KSR1; RSU2
UniProt ID: (Human) Q8IVT5, (Mouse) Q61097
Entrez Gene ID: (Human) 8844, (Mouse) 16706
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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