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Product Details
BS-12181R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide derived from human Kir6.2 around the phosphorylation site of Thr224.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI842722; ATP-sensitive inward rectifier potassium channel 11; AW491124; beta-cell inward rectifier subunit; BIR; IKATP; Inward rectifier K(+) channel Kir6.2; inwardly rectifying potassium channel KIR6.2; IRK11; KATP; KATP channel; MGC133230; potassium channel inwardly rectifing subfamily J member 11; Potassium channel, inwardly rectifying subfamily J member 11; potassium channel, inwardly rectifying subfamily J, member 11; potassium inwardly rectifying channel, subfamily J, member 11; potassium inwardly-rectifying channel subfamily J member 11; potassium inwardly-rectifying channel, subfamily J, member 11
Gene Aliases: BIR; HHF2; IKATP; KCNJ11; KIR6.2; mBIR; MODY13; PHHI; TNDM3
UniProt ID: (Human) Q14654, (Rat) P70673, (Mouse) Q61743
Entrez Gene ID: (Human) 3767, (Rat) 83535, (Mouse) 16514
voltage-gated potassium channel activity
ATP binding
protein C-terminus binding
ATP-activated inward rectifier potassium channel activity
ankyrin binding
potassium ion binding
heat shock protein binding
ion channel binding
protein binding
G-protein activated inward rectifier potassium channel activity
inward rectifier potassium channel activity
voltage-gated ion channel activity
ion channel
transporter
response to ischemia
glucose metabolic process
potassium ion import
response to estradiol
response to ATP
response to testosterone
regulation of membrane potential
response to drug
negative regulation of insulin secretion
regulation of insulin secretion
neurological system process
transmembrane transport
cellular response to nicotine
cellular response to glucose stimulus
cellular response to tumor necrosis factor
potassium ion transmembrane transport
regulation of cardiac conduction
positive regulation of cation channel activity
potassium ion transport
regulation of ion transmembrane transport
transport
ion transport
Performance Guarantee
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