L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosterones in androgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.
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Protein Aliases: 65 kDa macrophage protein; bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); DKFZp781A23186; epididymis secretory protein Li 37; FLJ25423; FLJ26114; FLJ39956; L-fimbrin; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); LC64P; LCP-1; Lymphocyte cytosolic protein 1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; plastin 2, L; Plastin-2; pp65
Gene Aliases: AW536232; CP64; D14Ertd310e; HEL-S-37; L-PLASTIN; LC64P; LCP-1; LCP1; LPL; PLS2; pp65