Linker for activation of T cells (LAT) is a 36 kDa transmembrane adapter protein that is tyrosinephosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (Y132, Y171, Y191 and Y226 in human LAT) are crucial for its activity and subsequent signaling to downstream molecules. Tyrosine 191 has been shown to play a key role inT cell activation, and to mediate Grb2 binding and Gads recruitment, thus mediating SLP-76 Binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; linker for activation of T cells; linker for activation of T cells, transmembrane adaptor; Linker for activation of T-cells family member 1; linker protein; p36-38; pp36
Gene Aliases: LAT; LAT1; pp36