This antibody is predicted to react with non-human primate, mouse and rat based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
LRRK2 belongs to the leucine-rich repeat kinase family commonly known as Dardarin. The LRRK2 gene encodes for a protein with an ankyrin-repeat region, a leucine-rich repeat region, a kinase domain, a RAS domain, a GTPase-domain, a MLK-like domain, and a WD40 domain. Proteins with leucine-rich regions play important roles in activities that require protein-protein interactions, such as transmitting signals or helping to assemble the cell's structural framework. Phosphorylation of LRRK2 at multiple sites including serine 910 and serine 935 regulates LRRK2 mediated cellular activities by affecting binding of dimeric 14-3-3 protein. Phosphorylation at Ser910, found to be constitutive in various tissues, is caused by protein kinase A. In humans, he gene is present on the q arm of chromosome 12.
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Protein Aliases: augmented in rheumatoid arthritis 17; BC 300-268; Dardarin; Leucine-rich repeat kinase 2; Leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; LRRK-2; PARK8; ROCO2
Gene Aliases: AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2
UniProt ID: (Human) Q5S007
Entrez Gene ID: (Human) 120892