Phospho-MBL2 (Thr232) Polyclonal Antibody detects endogenous levels of MBL2 only when phosphorylated at Thr232.
MBL2 is a calcium-dependent lectin involved in innate immune defense. It binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. It also binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. MBL2 may bind DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: COLEC1; Collectin-1; mannan-binding lectin; Mannan-binding protein; mannose binding lectin (C); mannose binding lectin 2 (protein C); mannose binding lectin, liver (C); Mannose-binding lectin; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannose-binding lectin 2, soluble (opsonic defect); Mannose-binding protein C; mannose-binding protein C (liver); MBP-C; MBP1; RA-reactive factor P28A subunit; Ra-reactive factor polysaccharide-binding component p28A; RaRF p28A; RARF/P28A
Gene Aliases: Ab2-001; Ab2-011; COLEC1; HSMBPC; L-MBP; MBL; MBL-C; MBL2; MBL2D; MBP; MBP-C; MBP1; MBPD
Molecular Function: defense/immunity protein