A suggested positive control for Western blot is rat or mouse brain cells.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
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Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 5; HsT17454; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPK/ERK kinese 5; MAPKK 5; MAPKK5; MEK 5; MEK5; mitogen activated protein kinase kinase 5; PRKMK5
Gene Aliases: AI324775; AI428457; HsT17454; MAP2K5; MAPKK5; MEK5; MKK5; PRKMK5