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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of serine 207 (V-D-S(p)-V-A) derived from Human MKK6.|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for Western blot is HL60 cells; suggested positive control for IHC is human breast carcinoma; suggested positive control for ICC/IF is Hela cells.
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases, act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen-activated protein kinase kinase 6; kinase 6 (MAP kinase kinase 6); MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MAPKK3; MAPKK6; MEK 3; MEK 6; MEK3; MEK6; mitogen activated protein kinase kinase 6; mitogen-activated; MKK3; MKK6; PRKMK3; PRKMK6; protein kinase; protein kinase, mitogen activated, kinase 6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 2; SAPK kinase 3; SAPKK-2; SAPKK-3; SAPKK2; stress-activated protein kinase kinase 2; stress-activated protein kinase kinase 3
MAP2K6; MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3; SKK3