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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of tyrosine 749/681(K-I-Y(p)-S-G) derived from Human MER/SKY .|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for Western blot is NIH-3T3 cells; suggested positive control for IHC is human brain tissue.
SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bruton agammaglobulinemia tyrosine kinase; c-mer; c-mer proto-oncogene tyrosine kinase; EC 220.127.116.11; kinase Syk; KSYK; MER; MER receptor tyrosine kinase; proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; STK kinase; SYK; Tyro 12; TYRO3 protein tyrosine kinase 3; tyrosine-protein kinase byk; tyrosine-protein kinase DTK; tyrosine-protein kinase Mer; tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase RSE; tyrosine-protein kinase SKY; tyrosine-protein kinase TIF
AI323366; Brt; BYK; c-Eyk; c-mer; DTK; Etk-2; etk2/tyro3; Eyk; MER; MERTK; nmf12; Nyk; rdy; Rek; RP38; RSE; SKY; TIF; TK19-2; Tyro12; TYRO3