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Invitrogen
Phospho-MLK1/MLK2 (Thr312, Thr266) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-MLK1/MLK2 (Thr312, Thr266) Antibody (PA5-37818) in IHC (P)
Immunohistochemical analysis of Phospho-MLK1/MLK2 (Thr312, Thr266) in paraffin-embedded Human brain tissue using Phospho-MLK1/MLK2 (Thr312, Thr266) Polyclonal Antibody (Product # PA5-37818) (left) or the same antibody preincubated with blocking peptide (right).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-37818
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of threonine 312/266(A-G-T(p)-Y-A) derived from Human MLK1/2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for IHC is human brain tissue.
Target Information
MLK is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mixed lineage kinase 1 (tyr and ser/thr specificity); mixed lineage kinase 2; MKN28 derived nonreceptor_type; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; protein kinase; protein kinase MST; serine/threonine kinase; unnamed protein product
Gene Aliases: E130314H24Rik; MEKK10; MEKK9; MLK1; MLK2; MST; PRKE1
UniProt ID: (Human) Q02779, (Human) P80192, (Mouse) Q66L42, (Mouse) Q3U1V8
Entrez Gene ID: (Human) 4294, (Human) 4293, (Mouse) 269881, (Mouse) 338372
transcription corepressor activity
protein kinase activity
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
bHLH transcription factor binding
protein serine kinase activity
MAP kinase kinase activity
molecular function activator activity
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
protein phosphorylation
signal transduction
smoothened signaling pathway
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of apoptotic process
positive regulation of JUN kinase activity
negative regulation of transcription, DNA-templated
positive regulation of JNK cascade
protein autophosphorylation
apoptotic process
JNK cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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