|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of threonine 312/266(A-G-T(p)-Y-A) derived from Human MLK1/2.|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
A suggested positive control for IHC is human brain tissue.
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
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Protein Aliases: MAP3K9; MEKK9; mitogen activated protein kinase kinase kinase 9; Mitogen-activated protein kinase kinase kinase 10; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity); Mixed lineage kinase 2; MKN28 derived nonreceptor_type; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK1; PRKE1; Protein kinase MST; serine/threonine kinase
Gene Aliases: BC028668; BC046514; E130314H24Rik; MAP3K10; MAP3K9; MEKK10; MEKK9; MLK1; MLK2; MST; PRKE1
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