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7TM Antibodies
Phospho-MRGPRX2 Mas-related Receptor (Ser327, Ser328) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-MRGPRX2 Mas-related Receptor (Ser327, Ser328) Antibody (7TM0157B) in WB
Agonist-induced Serine327/Serine328 phosphorylation of the MRGPRX2 Mas-related Receptor. Upper panel, HEK293 cells stably expressing the MRGPRX2 Receptor (MRGPRX2) were either not exposed or exposed to 100 nM specific Agonist ZINC-3573 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS327/pS328-MRGPRX2 antibody (7TM0157B) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed... View More
Product Details
7TM0157B
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human MRGPRX2 around the phosphorylation site of Ser327/Ser328.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein-coupled receptor MRGX2; Mas-related G protein-coupled receptor G3; Mas-related G-protein coupled receptor member X2; MAS-related GPR, member X2
Gene Aliases: MGRG3; MRGPRX2; MRGX2
UniProt ID: (Human) Q96LB1
Entrez Gene ID: (Human) 117194
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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