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Antibody detects endogenous levels of MSK2 only when phosphorylated at Thr687.
RPS6KA4 (MSK2) is a serine/threonine protein kinase that is essential for the regulation of various cellular processes. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. RPS6KA4 contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
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Protein Aliases: 90 kDa ribosomal protein S6 kinase 4; coiled-coil domain containing 88B; EC 2.7.11.1; kinase MSK2; KS6A4; mitogen- and stress-activated protein kinase 2; mitogen- and stress-activated protein kinase-2; Nuclear mitogen- and stress-activated protein kinase 2; Ribosomal protein kinase B; ribosomal protein S6 kinase alpha 4; Ribosomal protein S6 kinase alpha-4; ribosomal protein S6 kinase, 90kD, polypeptide 4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; RLSK; RSK-like protein kinase; RSKB; S6K-alpha-4
Gene Aliases: 1110069D02Rik; 90kDa; AI848992; Ccdc88b; mMSK2; MSK2; RPS6KA4; RSK-B; S6K-alpha-4
UniProt ID: (Human) O75676, (Mouse) Q9Z2B9
Entrez Gene ID: (Human) 8986, (Mouse) 56613, (Rat) 361715
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