This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate and Xenopus based on 100% sequence homology.
In Western blot, this antibody is specific for the ~65 kDa Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
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Protein Aliases: EIEE4; FLJ37475; hUNC18; MGC146482; munc-18c; N-Sec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; rop; RP11-56D16.3; Syntaxin-binding protein 1; unc-18 homolog; unc-18-1; Unc-18A; Unc18-1
Gene Aliases: ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A; rbSec1; rbSec1A; rbSec1B; Sec1; Stxbp1; Unc18-1; Unc18a
UniProt ID: (Rat) P61765
Entrez Gene ID: (Rat) 25558