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NACA prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). It binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. NACA also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites), and may act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-NAC; Alpha-NAC, muscle-specific form; Alpha-NAC/1.9.2; Hom s 2; NAC-alpha; nascent polypeptide-associated complex alpha subunit; Nascent polypeptide-associated complex subunit alpha; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; nascent-polypeptide-associated complex alpha polypeptide; skNAC
Gene Aliases: AL022831; AL024382; Gm1878; HSD48; mKIAA0363; NAC-alpha; NACA; NACA1; skNAC
Molecular Function: basic helix-loop-helix transcription factor