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Western blot analysis of Phospho-NMDA Receptor 2C pSer1244 in rat cerebellum lysate using a Phospho-NMDA Receptor 2C pSer1244 polyclonal antibody (Product # PA5-35403). Results show a band at ~140kDa. The phosphospecificity is shown in the second lane where immunoreactivity is blocked by preadsorption with the phospho-peptide used as antigen but not by the dephosphopeptide (not shown).
|Tested species reactivity||Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1244 of rat GRIN2C conjugated to KLH|
|Storage buffer||0.1M HEPES, pH 7.5, with 50% glycerol, 0.1mg/ml BSA, 0.15M NaCl|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with bovine and canine based on 100% sequence homology.
This antibody contains enough material to conduct 10 mini-Western blots.
The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
GluRepsilon3; glutamate [NMDA] receptor subunit epsilon-3; Glutamate NMDA receptor subunit epsilon-3; Glutamate receptor ionotropic NMDA 2C; glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, NMDA2C; Grin2c; N-methyl D-aspartate receptor subtype 2C; N-Methyl-D-Aspartate Receptor Type 2C; NMDA glutamate receptor; NMDAR2C; NR2C
GluN2C; Grin2c; NMDAR2C; NR2C