PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.
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Protein Aliases: 2; 3; adriamycin resistance-associated; Alpha-PAK; Beta-PAK; C-t-PAK2; Gamma-PAK; Oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 2; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 1; p21-activated kinase 2; p21-activated kinase 3; p21-Activated Protein Kinase-1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p58; p65-PAK; PAK-1; PAK-2; PAK-2p27; PAK-2p34; PAK-3; Pak1; Pak2; Pak3; PAK65; S6/H4 kinase; Serine/threonine-protein kinase PAK 1; Serine/threonine-protein kinase PAK 2; Serine/threonine-protein kinase PAK 3; STE20 homolog, yeast
Gene Aliases: ARA; beta-PAK; bPAK; MRX30; MRX47; OPHN3; PAK-3; PAK1; PAK2; PAK3; PAK3beta; PAK65; PAKalpha; PAKgamma