A suggested positive control for IHC is human breast carcinoma.
PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. PAK2 is activated by proteolytic cleavage during caspase-mediated apoptosis and may play a role in regulating the apoptotic events in the dying cell.
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Protein Aliases: C-t-PAK2; Gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 CDKN1A-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p27; p34; p58; PAK-2; PAK-2p27; PAK-2p34; PAK65; PAKgamma; S6/H4 kinase; Serine/threonine-protein kinase PAK 2
Gene Aliases: 5330420P17Rik; A130002K10Rik; AI836325; D16Ertd269e; gamma-PAK; mKIAA4182; PAK-2; PAK2; PAK65; PAKgamma