Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
Assay-dependent | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20 | - |
Immunohistochemistry (Frozen) (IHC (F)) |
- | View 1 publication 1 publication |
ELISA (ELISA) |
Assay-dependent | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic phospho-peptide derived from the sequence surrounding the phosphorylated Ser393 residue of mouse and human Pax2 (paired box protein 2). Ser393 of the 415 amino acid mouse Pax2 isoform is equivalent to Ser394 of the 416 amino acid human Pax2 isoform, and to Ser371 of the 393 amino acid human Pax2 isoform. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.25 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.4 |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2533286 |
The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: optic disc coloboma; paired box gene 2; paired box homeotic gene 2; Paired box protein Pax-2
Gene Aliases: FSGS7; Opdc; PAPRS; Pax-2; PAX2
UniProt ID: (Human) Q02962, (Mouse) P32114
Entrez Gene ID: (Human) 5076, (Mouse) 18504, (Rat) 293992
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