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Lysates of PMA-stimulated Cos7 cells transfected with HA-tagged wild-type PED/PEA-15 (A), His-tagged S104A mutant PED/PEA-15 (B), and His-tagged S116A mutant PED/PEA-15 (C). Absence of signal in PED/PEA-15 S116A mutant demonstrates antibody specificity.
|Tested species reactivity||Mouse, Human|
|Published species reactivity||Rat, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human PED/PEA-15 that contains serine 116. The sequence is conserved in mouse and rat.|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol|
|Contains||0.05% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
FADD adaptor and PEA-15/ERK1/2 partners in major depression and schizophrenia postmortem brains: basal contents and effects of psychotropic treatments.
44-836G was used in western blot to investigate Fas-associated death domain in patients with major depression and schizophrenia
|Garc?a-Fuster MJ,D?ez-Alarcia R,Ferrer-Alc?n M,La Harpe R,Meana JJ,Garc?a-Sevilla JA||Neuroscience (277:541)||2014|
|Rat||Not Cited||The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity.||Ramos-Miguel A,Esteban S,García-Sevilla JA||European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (20:49)||2010|
15 kDa phosphoprotein enriched in astrocytes; 15kD; astrocytic phosphoprotein PEA-15; homolog of mouse MAT-1 oncogene; mammary transforming gene 1; OTTHUMP00000029887; Phosphoprotein enriched in astrocytes; phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in astrocytes, 15kD; phosphoprotein enriched in diabetes
HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; Pea15; PED; Pkcs15; RP11-536C5.8