Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms ( alpha, betaI, betaII and gamma) and novel (n) PKC isoforms ( delta, epsilon, zeta, eta and theta). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC delta and epsilon are independent of Ca2+.
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Protein Aliases: 14 - 3 - 3 - zeta isoform; aging-associated gene 6; aPKC-lambda/iota; atypical protein kinase C; Atypical protein kinase C-lambda/iota; nPKC-delta; nPKC-epsilon; nPKC-eta; nPKC-iota; nPKC-theta; nPKC-zeta; PKC theta; PKC zeta; PKC-A; PKC-alpha; PKC-B; PKC-beta; PKC-gamma; PKC-L; PRKC-lambda/iota; Protein kinase C alpha type; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; protein kinase C beta-II; Protein kinase C delta type; Protein kinase C delta type catalytic subunit; Protein kinase C delta type regulatory subunit; protein kinase C delta variant IX; protein kinase C delta VIII; Protein kinase C epsilon type; Protein kinase C eta type; Protein kinase C gamma type; Protein kinase C iota type; Protein kinase C theta type; protein kinase C type I (gamma type); protein kinase C zeta subspecies; Protein kinase C zeta type; protein kinase C, alpha; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase C, delta; protein kinase C, delta IV; protein kinase C, delta V; protein kinase C, epsilon; protein kinase C, eta; protein kinase C, gamma; protein kinase C, iota; protein kinase C, lambda; protein kinase C, theta; protein kinase C, zeta; protein kinase c-alpha; protein kinase C-eta; protein kinase C[d]; SDK1; Sphingosine-dependent protein kinase-1; Tyrosine-protein kinase PRKCD
Gene Aliases: 14-3-3-zetaisoform; 2310021H13Rik; 5830406C15Rik; A130035A12Rik; A130082F03Rik; AAG6; AI098070; AI385711; AI427505; AI875142; ALPS3; aPKClambda; aPKCzeta; AW494342; C80388; CVID9; D14Ertd420e; DXS1179E; MAY1; mKIAA4165; nPKC-delta; nPKC-epsilon; nPKC-eta; nPKC-iota; nPKC-theta; nPKC-zeta; PKC; PKC-0; PKC-alpha; PKC-Beta; PKC-gamma; PKC-L; PKC-theta; PKC-ZETA; PKC2; PKC[d]; PKC[e]; PKCA; PKCB; PKCC; PKCD; PKCdelta; PKCE; Pkcea; PKCepsilon; PKCG; PKCgamma; Pkch; PKCI; PKCL; PKClambda; Pkcq; PKCtheta; Pkcz; PRKACA; Prkc; PRKCA; PRKCB; PRKCB1; PRKCB2; Prkcc; PRKCD; PRKCE; PRKCG; PRKCH; PRKCI; PRKCL; PRKCQ; PRKCT; PRKCZ; r14-3-3; R74924; R75156; RATPKCI; SCA14; zetaPKC
UniProt ID: (Human) P17252, (Human) P05771, (Human) Q05655, (Human) Q02156, (Human) P05129, (Human) P24723, (Human) P41743, (Human) Q04759, (Human) Q05513, (Mouse) P20444, (Mouse) P68404, (Rat) P68403, (Mouse) P28867, (Rat) P09215, (Mouse) P16054, (Rat) P09216, (Mouse) P63318, (Rat) P63319, (Mouse) P23298, (Rat) Q64617, (Mouse) Q62074, (Rat) F1M7Y5, (Mouse) Q02111, (Rat) P09217, (Mouse) Q02956
Entrez Gene ID: (Human) 5578, (Human) 5579, (Human) 5580, (Human) 5581, (Human) 5582, (Human) 5583, (Human) 5584, (Human) 5588, (Human) 5590, (Rat) 24680, (Mouse) 18750, (Mouse) 18751, (Rat) 25023, (Mouse) 18753, (Rat) 170538, (Mouse) 18754, (Rat) 29340, (Mouse) 18752, (Rat) 24681, (Mouse) 18755, (Rat) 81749, (Mouse) 18759, (Rat) 84006, (Rat) 85420, (Mouse) 18761, (Rat) 25522, (Mouse) 18762
Molecular Function: annexin calcium-binding protein calmodulin intracellular calcium-sensing protein kinase non-receptor serine/threonine protein kinase protein kinase transfer/carrier protein transferase