PA1-28462 detects PKC delta from human, rat, mouse samples.
PA1-28462 has been successfully used in Western blot applications. It detects a band approximately 77kDa.
The PA1-28462 immunogen is: Synthetic phosphopeptide derived from the region of human PKC delta that contains serine 645.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC57564; nPKC-delta; PKCC; PKCG; PRKCG; Protein kinase C delta type; Protein kinase C delta type catalytic subunit; Protein kinase C delta type regulatory subunit; protein kinase C delta variant IX; protein kinase C delta VIII; protein kinase C, delta; protein kinase C, delta IV; protein kinase C, delta V; protein kinase C[d]; SCA14; SDK1; Sphingosine-dependent protein kinase-1; Tyrosine-protein kinase PRKCD
Gene Aliases: AI385711; ALPS3; CVID9; D14Ertd420e; MAY1; nPKC-delta; PKC[d]; PKCD; PKCdelta; PRKCD
Molecular Function: annexin calcium-binding protein calmodulin intracellular calcium-sensing protein kinase non-receptor serine/threonine protein kinase protein kinase transfer/carrier protein transferase