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Product Details
PA5-36777
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide derived from human PKC delta around the phosphorylation site of Serine 645
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2553724
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 80 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-May; kinase nPKC-delta; KPCD; nPKC-delta; Protein kinase C delta type; Protein kinase C delta type catalytic subunit; Protein kinase C delta type regulatory subunit; protein kinase C delta VIII; protein kinase C, delta; SDK1; Sphingosine-dependent protein kinase-1; Tyrosine-protein kinase PRKCD
Gene Aliases: ALPS3; CVID9; MAY1; nPKC-delta; PKCD; PRKCD
UniProt ID: (Human) Q05655
Entrez Gene ID: (Human) 5580
Molecular Function:
non-receptor serine/threonine protein kinase
stimulatory C-type lectin receptor signaling pathway
protein phosphorylation
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
cell cycle
signal transduction
activation of phospholipase C activity
intrinsic apoptotic signaling pathway in response to oxidative stress
regulation of receptor activity
immunoglobulin mediated immune response
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
termination of signal transduction
platelet activation
negative regulation of actin filament polymerization
positive regulation of endodeoxyribonuclease activity
negative regulation of protein binding
activation of protein kinase activity
interleukin-10 production
interleukin-12 production
positive regulation of superoxide anion generation
regulation of actin cytoskeleton organization
negative regulation of glial cell apoptotic process
positive regulation of protein dephosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
B cell proliferation
neutrophil activation
positive regulation of protein import into nucleus
defense response to bacterium
negative regulation of MAP kinase activity
regulation of mRNA stability
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
negative regulation of peptidyl-tyrosine phosphorylation
protein stabilization
negative regulation of filopodium assembly
cell chemotaxis
interferon-gamma-mediated signaling pathway
cellular response to hydrogen peroxide
cellular response to hydroperoxide
negative regulation of platelet aggregation
cellular senescence
positive regulation of phospholipid scramblase activity
cellular response to angiotensin
positive regulation of ceramide biosynthetic process
positive regulation of glucosylceramide catabolic process
positive regulation of sphingomyelin catabolic process
positive regulation of response to DNA damage stimulus
positive regulation of apoptotic signaling pathway
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-independent protein kinase C activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
enzyme activator activity
enzyme binding
kinase binding
protein kinase binding
insulin receptor substrate binding
metal ion binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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