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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic phosphopeptide derived from human PKC-pan around the phosphorylation site of Thr497 (T-S-TP-F-C)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ and PRKCZ
Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms ( alpha, betaI, betaII and gamma) and novel (n) PKC isoforms ( delta, epsilon, zeta, eta and theta). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC delta and epsilon are independent of Ca2+.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
14 - 3 - 3 - zeta isoform; aging-associated gene 6; atypical protein kinase C; nPKC-delta; nPKC-epsilon; nPKC-eta; nPKC-theta; nPKC-zeta; PKC theta; PKC zeta; PKC-A; PKC-alpha; PKC-B; PKC-beta; PKC-gamma; PKC-L; PKCA; PKCB; PKCE; PKCG; PRKACA; PRKCA; PRKCB; PRKCB1; PRKCD; PRKCE; PRKCG; PRKCQ; PRKCT; PRKCZ; protein kinase C alpha type; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C beta-II; protein kinase C delta type; protein kinase C delta variant IX; protein kinase C delta VIII; protein kinase C epsilon type; protein kinase C eta type; protein kinase C gamma type; protein kinase C theta type; protein kinase C type I (gamma type); protein kinase C zeta subspecies; protein kinase C zeta type; protein kinase C, alpha; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase C, delta; protein kinase C, delta IV; protein kinase C, delta V; protein kinase C, epsilon; protein kinase C, eta; protein kinase C, gamma; protein kinase C, theta; protein kinase C, zeta; protein kinase c-alpha; protein kinase C-eta; protein kinase C[d]; SDK1; Sphingosine-dependent protein kinase-1; tyrosine-protein kinase PRKCD
14-3-3-zetaisoform; 5830406C15Rik; A130035A12Rik; A130082F03Rik; AAG6; AI098070; AI385711; AI875142; ALPS3; aPKCzeta; AW494342; C80388; CVID9; D14Ertd420e; MAY1; nPKC-delta; nPKC-epsilon; nPKC-eta; nPKC-theta; nPKC-zeta; PKC; PKC-0; PKC-alpha; PKC-Beta; PKC-gamma; PKC-L; PKC-theta; PKC-ZETA; PKC2; PKC[d]; PKC[e]; PKCA; PKCB; PKCC; PKCD; PKCdelta; PKCE; Pkcea; PKCepsilon; PKCG; PKCgamma; Pkch; PKCI; PKCL; Pkcq; PKCtheta; Pkcz; PRKACA; Prkc; PRKCA; PRKCB; PRKCB1; PRKCB2; Prkcc; PRKCD; PRKCE; PRKCG; PRKCH; PRKCL; PRKCQ; PRKCT; PRKCZ; r14-3-3; R74924; R75156; RATPKCI; SCA14; zetaPKC
(Human) P17252, (Human) Q9UE49, (Human) Q05655, (Human) Q02156, (Human) P05129, (Human) P24723, (Human) Q04759, (Human) Q05513, (Mouse) P20444, (Mouse) P68404, (Rat) P68403, (Rat) P09215, (Mouse) P28867, (Mouse) P16054, (Rat) P09216, (Rat) P63319, (Mouse) P63318, (Mouse) P23298, (Rat) Q64617, (Mouse) Q02111, (Rat) P09217, (Mouse) Q02956
(Human) 5578, (Human) 5579, (Human) 5580, (Human) 5581, (Human) 5582, (Human) 5583, (Human) 5588, (Human) 5590, (Rat) 24680, (Mouse) 18750, (Mouse) 18751, (Rat) 25023, (Rat) 170538, (Mouse) 18753, (Mouse) 18754, (Rat) 29340, (Rat) 24681, (Mouse) 18752, (Mouse) 18755, (Rat) 81749, (Rat) 85420, (Mouse) 18761, (Rat) 25522, (Mouse) 18762